Principali fonti bibliografiche sulla Mucosite Orale e sulle proprietà terapeutiche di PVP, Verbascoside e Sodio jaluronato.

Efficacy of a solution composed by Verbascoside, Polyvinylpyrrolidone and sodium hyaluronate (Mucosyte®) in the treatment of chemotherapy-induced Oral Mucositis in Children with acute lymphoblasticLeukemia

E. Bardellini, F. Amadori, R.F. Schumaker, Carmelita D’Ippolito, F. Porta, A. Majorana
Journal Pediatric Hematology Oncology - Sept 2016

Clinical efficay of a Medical Device (Mucosyte®) in the treatment of chemotherapy-induced oral mucositis in children

A. Majorana, E. Bardellini, F. Amadori, N. Pedrini, F.Gorla, R.F. Schumaker, F. Porta
MASCC 2015 - Copenhagen - DK

Prevention of Oral Mucositis in Cancer Patients - Clinical application of an anti-inflammatory agent (Mucosyte®)

G.Pasini, G.Rossi, G.Citterio
MASCC 2015 - Copenhagen - DK

The role of (Mucosyte®) in Patients with Oral Mucositis under chemotherapy and/or Radiotherapy

M. Vaslamatzis, T.H. Tegos, N. Alevizopoulos, A. Dimitriadou, C.H. Stathoupoulos, A. Lasharakis, C.H. Zoumblios, D. Protonotarios, O.U. Nikolatou
MASCC 2015 - Copenhagen - DK

Oral Mucositis related to Radiotherapy for Head and Neck: Evaluation of the effectiveness of a new anti-inflammatory product (Mucosyte®)

Di Franco R, Matteo M, Ravo V, Borrelli D, Pepe A, Falivene S, Argenone A, Guida G, Muto P
7° MASCC/ISOO Meeting - Miami USA June 26-28 2014

Verbascoside down-regulates some pro-inflammatory signal transduction pathways by increasing the activity of SHP-1 in the U937 cell line

Speranza L, Pesce M, Franceschelli S, Ferrone A, De Lutiis MA, Patruno A, Grilli A, Felaco M
Journal of Cellular and Molecular Medicine, Nov. 2014

Azione antinfiammatoria del Verbascoside su una linea cellulare mielomonocitica umana (THP-1)

Speranza L, Franceschelli S, De Lutiis MA, Pesce M, Vinciguerra I, Patruno A, Menghini L, Grilli a, Felaco M.
XI Congr Naz AIBG 8-11, Ott 2009 Palermo

Antinflammatory  effects in U937 cells treated with Verbascoside

Speranza L, Franceschelli S, Pesce M, Farrone A,  De Luts MA, Felaco M, GriIIi A.
Dept Med Sci. Ag., Univ. D’Annunzio-Chieti  Italy

Anti-inflammatory properties of the plant Verbascum mallophorum 
Speranza L, Franceschelli S, Pesce M, Menghini L, Patruno A, Vinciguerra I, De Lutiis MA, Felaco M, Felaco P, Grilli A.
J Biol Regul Homeost Agents. 2009 Jul-Sep;23(3):189-95

The antiinflammatory action in THP-1 cells treated with of Verbascoside
Speranza L, Felaco M , Menghini L , Patruno A , Epifano F , Reale M, Franceschelli S, Pesce M, Vinciguerra I, De Lutiis MA and Grilli A
Phytotherapy Research. 2010 Sep 24(9):1398-404

Purification, stability and antifungal activity of Verbascoside from Lippia javanica and Lantana camara leaf extracts

Oyourou, J.N.; Combrinck, S.; Regnier, T.; Marston, A.
Industrial Crops & Products vol. 43 May, 2013. p. 820-826

Verbascoside isolated from Tectona grandis mediates gastric protection in rats via inhibiting proton pump activity 

Singh, N.; Shukla, N.; Singh, P.; Sharma, R.; Rajendran, S.M.; Maurya, R.; Palit, G.
Fitoterapia vol. 81 issue 7 October, 2010. p. 755-761

Efficacy of treatment with Verbascoside, biotechnologically produced by Syringa vulgaris plant cell cultures in an experimental mice model of spinal cord trauma

Genovese, Tiziana; Paterniti, Irene; Mazzon, E.; Esposito, E.; Paola, R.; Galuppo, Maria; Bramanti, P.; Cuzzocrea, Salvatore.
Naunyn-Schmiedeberg's Archives of Pharmacology vol. 382 issue 4 October 2010. p. 331 - 345

Antiinflammatory effects in THP-1 cells treated with Verbascoside.

Speranza, Lorenza; Franceschelli, Sara; Pesce, Mirko; Reale, Marcella; Menghini, Luigi; Vinciguerra, Isabella; De Lutiis, Maria Anna; Felaco, Mario; Grilli, Alfredo.
Phytotherapy Research vol. 24 issue 9 September 2010. p. 1398-1404

Effects of Verbascoside, a phenylpropanoid glycoside from lemon verbena, on phospholipid model membranes

Funes, L.; Laporta, O.; Cerdan-Calero, M.; Micol, V.
Chemistry and Physics of Lipids vol. 163 issue 2 February, 2010. p. 190-199

Protective effect of Verbascoside in activated C6 glioma cells: possible molecular mechanisms

Esposito E.; Toso R.; Pressi G.; Bramanti P.; Meli R.; Cuzzocrea S.
Naunyn-Schmiedeberg's Archives of Pharmacology vol. 381 issue 1 January 2010. p. 93 – 105

Anti-inflammatory phenylpropanoid glycosides from Clerodendron trichotomum leaves

Kim, Kyoung Hee; Kim, Sungun; Jung, Min Young; Ham, In Hye; Whang, Wan Kyunn
Archives of Pharmacal Research vol. 32 issue 1 January 2009. p. 7 – 13

Verbascoside and Verminoside - induced genotoxicity on human lymphocytes: Involvement of PARP-1 and p53 proteins

Santoro A.; Bianco G.; Picerno P.; Aquino R.P.;Autore G.; Marzocco S.  Gazzerro P.; Lioi M.B.; Bifulco M.
Toxicology Letters vol. 178 issue 2 May 5, 2008. p. 71-76

Anti-inflammatory and anti-ulcerogenic properties of Stachytarpheta cayennensis (L.C. Rich) Vahl

Penido, C.; Costa, K.A.; Futuro, D.O.; Paiva, S.R.; Kaplan, M.A.C.; Figueiredo, M.R.; Henriques, M.G.M.O.
Journal of Ethnopharmacology vol. 104 issue 1-2 March 8, 2006. p. 225-233

The effects of Verbascoside on plasma lipid peroxidation level and erythrocyte membrane fluidity during immobilization in rabbits: a time course study 

Liu, Ming-Ju; Li, Jing-Xian; Guo, Hong-Zhu; Lee, Kwong-Man; Qin, Ling; Chan, Kai-Ming
Life Sciences vol. 73 issue 7 July 4, 2003. p. 883-892

Antiinflammatory activity and chemical composition of extracts of Verbena officinalis

Deepak, Mundkinajeddu; Handa, Sukhdev Swami.
Phytotherapy Research vol. 14 issue 6 September 2000. p. 463 - 465

Mechanism of action of Verbascoside on the isolated rat heart: increases in level of prostacyclin

Pennacchio, M.; Syah, Y. M.; Alexander, E.; Ghisalberti, E. L.
Phytotherapy Research vol. 13 issue 3 May 1999. p. 254 - 255

The effect of Verbascoside on cyclic 3′,5′-adenosine monophosphate levels in isolated rat heart

Pennacchio, Marcello; Alexander, Elizabeth; Syah, Yana M.; Ghisalberti, Emilio L.
European Journal of Pharmacology vol. 305 issue 1-3 June 3, 1996. p. 169-171

PPAR-a Contributes to the anti-inflammatory activity of Verbascoside in a model of inflammatory bowel disease in mice

Esposito E., Mazzon E., Paterniti I., Dal Toso R., Pressi G., Caminiti R., Cuzzocrea S.
PPAR Research – Vol 2010 – ID 917312

Wound healing potential of Verbena Officinalis methanolic extract in rats

Sanay P.; Jayaveera K.N.; Kumar G.S.
Int. J Chem Sci 2007 – 5, 1295-1300

Molecular mechanisms underlying wound healing and anti-inflammatory properties of naturally occurring biotechnologically produced phenylpropanoid glycosides (Verbascoside)  

Korkina LG, Mikhal'chik E, Suprun MV, Pastore S, Dal Toso R.
CellMol.Biol. 2007 May 30;53(5):84-91

Protective effect of Verbascoside on 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells

Sheng, Guo-Qing; Zhang, Jin-Rong; Pu, Xiao-Ping; Ma, Jian; Li, Chang-Ling. Europ Journal of Pharm vol. 451 issue 2 September 13, 2002. p. 119-124

The neuroprotective effects of verbascoside, one of phenylpropanoid glucoside isolated from the Chinese herbal medicine Buddleja officinalis Maxim, on 1-methyl-4-phenylpyridinium ion (MPP+) induced apotosis and oxidative stress in PC12 neuronal cells were investigated. Treatment of PC12 cells with MPP+ for 48 h induced apoptotic death as determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and flow cytometry, the activation of caspase-3 measured by the caspase-3 activity assay kit, the reduction in mitochondrial membrane potential with laser scanning confocal microscopy and the increase in the extracellular hydrogen peroxide level. Simultaneous treatment with verbascoside markedly attenuated MPP+-induced apoptotic death, increased extracellular hydrogen peroxide level, the activation of caspase-3 and the collapse of mitochondrial membrane potential. These results strongly indicate that verbascoside may provide a useful therapeutic strategy for the treatment of oxidative stress-induced neurodegenerative disease such as Parkinson's disease.