These sequelae result in the need for supportive interventions. Mucositis also may be associated with increased risk for poorer outcome of cancer treatment due to the need for treatment interruption in some patient cohorts.
Frequencies of oral mucositis are estimated at
- 85% - 100% (25% - 45% grade 3/4) in the setting of head and neck high-dose radiation therapy
- 75% - 100% (25% - 60% grade 3/4) in stem cell transplantation
- 5% - 40% (5% - 15% grade 3/4 ) in patients receiving myelosuppressive chemotherapy for solid tumors.
Guidelines for treatment - prevention
Traditional management of oral mucositis has involved patient education and compliance:
- Excellent oral hygiene
- use of non-alcoolic mouthwashes
- Topical protective agents and systemic agents for pain control
- Hydration nutritional support, and infection surveillance and treatment.
Risk of Oral Mucositis (2006)
Peterson DE – J Supp Onc